Pour water into the Instant Pot.
Add sweet potatoes to a steamer basket, and place the basket in the Instant Pot. Alternatively, place the sweet potato quarters on a trivet.
Lock the lid, turn the knob to Sealing, and cook on Manual High pressure for 35 minutes*.
Preheat the oven to 375.
Prepare streusel in the last couple minutes of pressure cooking by combining all ingredients in a bowl and mixing to combine.
Turn the knob on the Instant Pot lid to Venting and perform a quick release.
Lift the basket out of the instant Pot and place on a plate or towel. Drain the dirty water out of the Instant Pot liner and rinse or wash. Return the liner to the Instant Pot base and add the butter, sugar, salt, cinnamon, and vanilla.
Using a paring knife, carefully peel the sweet potatoes and return back to the Instant Pot on top of the butter. The residual heat will melt the butter. Using a hand mixer or potato masher, blend sweet potatoes until fluffy and creamy. Add the beaten eggs while mixing to combine.
Spray a 9×13 pan with nonstick spray, and spread the mixture evenly.
Add a generous layer of the streusel topping and bake for 30-35 minutes until the streusel is firm and golden.
Let cool for 10 minutes to set, and enjoy.